Aspirin and cancer: trials and observational studies.
نویسنده
چکیده
منابع مشابه
Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies.
BACKGROUND Randomised trials have shown that aspirin reduces the short-term risk of recurrent colorectal adenomas in patients with a history of adenomas or cancer, but large trials have shown no effect in primary prevention of colorectal cancer during 10 years' follow-up. However, the delay from the early development of adenoma to presentation with cancer is at least 10 years. We aimed to asses...
متن کاملReview: evidence from observational studies, but not randomized trials, suggests that long-term aspirin prevents colorectal cancer.
M e t h o d s Data sources: MEDLINE (to December 2006), preMEDLINE (to April 2005), EMBASE/Excerpta Medica (to April 2005), the Cochrane Library (Issue 4, 2004), and the PubMed Cancer subset. Study selection and assessment: Englishlanguage studies that evaluated the efficacy of aspirin for primary prevention of colorectal cancer in persons at “average” risk and systematic reviews that assessed ...
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Background: Preeclampsia is one of the most common causes of maternal mortality. This complication has been attempted to prevent preeclampsia. Many drug treatments have also been tested, including aspirin, one of the drugs prescribed to prevent preeclampsia. Therefore, the present study was designed to summarize the findings and co...
متن کاملAspirin and colorectal cancer: back to the future.
Abundant epidemiologic evidence indicates that regular and long-term use of aspirin is associated with a significant reduction in the incidence of colorectal cancer. The long duration of aspirin needed to prevent colorectal cancer is believed to be due to inhibition of precursor lesions known as adenomas, the recurrence of which is inhibited by aspirin in randomized trials. Aspirin intake has a...
متن کاملMolecular pathways: aspirin and Wnt signaling-a molecularly targeted approach to cancer prevention and treatment.
The anti-inflammatory properties of aspirin have resulted in its widespread use as an analgesic, antipyretic, and cardioprotective agent. Beyond these applications, multiple observational studies and randomized controlled trials have demonstrated a chemopreventative role for aspirin, particularly in the development of colorectal neoplasia. Given the critical importance of Wnt dysregulation in c...
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عنوان ژورنال:
- Journal of the National Cancer Institute
دوره 104 16 شماره
صفحات -
تاریخ انتشار 2012